Endocrine Abstracts

Background: Hypopituitarism is characterised by multiple pituitary hormone deficiencies causing adverse metabolic milleu and body composition changes. Aim: Our aim was to investigate the gender related differences in the prevalence of metabolic syndrome (MetS) and metabolic profiles in patients with hypopituitarism compared to obese controls. Patients and methods: A retrospective study of 282 patients with hypopituitarism (136 wome...

Introduction: Hashimoto thyroiditis (HT), chronic autoimmune disease, is related with impaired quality of life (QoL) regardless of euthyroid state. Some studies showed decreased levels of vitamin D in patients with HT which implies there is a relationship between vitamin D deficiency and HT. It remains unclear whether decreased levels of vitamin D are result of autoimmune process or are part of its cause.Aim: To investigate effect of vitamin D levels on ...

Introduction: The aim of the study was to establish the predictive factors for endocrine disease-induced hyponatremia.Patients and methods: Fifty-two patients with hyponatremia (Na <135 nmol/l) were referred to Department of Neuroendocrinology, University Clinical Center of Serbia from January 2015 to March 2023 (n=52; 31 females, 60%) mean age 60.5&pm;14.1 years, mean serum sodium level 124.9&pm;9.0 mmol/l. Seven patients (13.4%) with trans...

Introduction: Acromegaly is a rare chronic disease characterized by systemic comorbidity. As a chronic disease, which in most cases requires long-term treatment, it is often accompanied by musculoskeletal, metabolic, and cardiovascular diseases, as well as headaches, anxiety, and depression, which leads to impaired quality of life.Aim: Assessment of quality of life in patients with acromegaly compared to healthy controls.Materials ...

Background: A subset of patients with prolactinomas does not respond satisfactorily to first-line medical therapy with dopamine agonists (DA). DA resistance is defined as failure to normalize prolactin (PRL) levels and/or to achieve ≥50% reduction in maximal tumor diameter under maximally tolerated doses (or a weekly cabergoline dose of ≥3mg). The predictive factors for DA resistance are male gender and tumor invasiveness.Aim: To characterize...

Introduction: Considering the mitogenic potential of GH and IGF1, the safety profile of growth hormone therapy since the beginning of its use has been debated. From that point of view, adolescents in transition to adulthood who were treated in childhood for endocranial tumors or malignancies require special caution.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study spanning 18 years, we analyzed 251 childhood onset...